For what shall it profit a man, if he shall gain the whole world, and lose his own soul?
For what shall it profit a man,.... In the long run, in the issue of things, who by denying Christ, and his Gospel, may not only save his life for the present, but procure for himself great riches and wealth:
if he shall gain the whole world; were that possible to be done, and which the ambitious, worldly man is desirous of; yet supposing he: had his desire, of what avail would this be in the upshot of things, should the following be his case, as it will,
and lose his own soul? which is immortal and everlasting, when the world, and the glory of it pass away, and so is of more worth than the whole world. The world can only be enjoyed for a season, and that with a great deal of fatigue and trouble; but the soul continues for ever; and if it is lost and damned, its torment always abides, and the smoke of it ascends for ever, its worm never dies, and its fire is never quenched; See Gill on "Matthew 16:26".